This study sought to investigate the relationship between parental support and students' academic performance in secondary schools located in Isingiro District, Uganda. Academic success is dependent on many factors, with parental involvement recognized as playing an influential role especially during adolescents' schooling years. However, the nature and extent of parental contributions to learning in this region have not been well established. A mixed methods approach incorporating both quantitative and qualitative data collection techniques was utilized. A sample of 63 students from 4 randomly selected schools participated in surveys to self-report levels of parental academic support and end of term grades from the previous year. In addition, 10 teachers and 4 administrators took part in in-depth interviews to provide a more well-rounded understanding of parental involvement patterns and perceived impacts on achievement outcomes. The results of the statistical analyses revealed a moderate positive correlation between measures of parental support, including supervision of homework, provision of scholastic materials, communication with teachers, and students' overall academic performance. Qualitative findings expanded on these relationships, shedding light on specific involvement activities observed to motivate learning along with continuing barriers to parents playing stronger educational roles. Examining the coefficients table, the constant value or Y-intercept was 1.905, meaning predicted academic performance was 1.905 when the predictor values were zero. Cultural values make the strongest unique contribution with a statistically significant coefficient of 0.722. Parenting styles had a coefficient of 0.093 but its contribution was not statistically significant based on the significance value of 0.078. It was recommended that schools prioritize developing formal structures and avenues to systematically facilitate enhanced parental engagement. Establishing organized parent-teacher associations, scheduling regular parent-teacher conferences, implementing school-led parental academic workshops, and utilizing modern communication platforms can help fortify consistent two-way ties between the educational stakeholders.