This research report study aimed to investigate the “Impact of e-commerce on business performance; A case study of Airtel Uganda”. Questionnaires were used to collect data under a case study research design. Qualitative and quantitative means were used to analyze the data. The objectives of the study used were; To examine the relationship between quality dimension and business performance, to assess the impact of e-commerce on customer satisfaction of Airtel Uganda Ltd, to examine the role of e-commerce on the profitability of Airtel Uganda Ltd. To achieve this objective, the study sampled 60 respondents because it is large enough compared to the study population that is 3 management executives, 10 staff members and 47 clients of Airtel-Uganda, the respondents were selected using simple purposive sampling method, it was important because it gave the researcher freedom to select certain respondents with in-depth knowledge regarding the issue under investigation. From the findings, 58% of the respondents strongly agreed that when customers are satisfied, they create a positive working environment, 42% agreed with the statement while none disagreed nor strongly disagreed with the statement. 42% of the respondents strongly agreed that website designing attracts customers to buy products since the products are easily accessible to everyone. 17% agreed with the statement, 25% strongly disagreed saying that what is on the website of some companies is not what is normally delivered while 17% disagreed. The researcher however recommends that the organization should blend the e-commerce strategy with other strategies like selling strategy so that it widely publicizes its ability to meet customer needs. This will attract more customers in a short run so as to further increase its profitability.