The study aimed at internal auditing practices and fraud management in organizations in uganda with a case study of Stanbic bank, nansana branch and it was guided by the following objectives; To examine the effect of control environment on fraud prevention in an organization, a case study of Stanbic Bank, Nansana branch, Wakiso District, to assess the effect of communication and information on fraud prevention in an organization, a case study of Stanbic Bank, Nansana branch, Wakiso District, to evaluate the effect of internal control activities on fraud prevention in an organization, a case study of Stanbic Bank, Nansana branch, Wakiso District and to analyze the relationship between internal auditing practices and fraud management in an organization, a case study of Stanbic Bank, Nansana branch, Wakiso District. This study used a research design called descriptive survey. Descriptive survey research designs were employed in exploratory and preliminary studies to permit the study to collect information, summarize, present and construe for the principal reason of clarification. From the findings, the constant 0.439, shown that keeping all other factors constant, fraud prevention of Stanbic Bank on average increased by 0.439. The coefficient 0.875 shown that a unit increase in the control environment would lead on average to 0.875 increases in the fraud prevention of an organization. The p-value (0.00) <0.05 (was statistically significant at 95% confidence level); this implied that; control environment had a significant impact on organizational fraud prevention expressed in form of customer authentication. The coefficient 0.049 shown that a unit increase in control environment on average led to 0.049 increase in sales volume. The researcher therefore recommends that Stanbic Bank should implement an effective internal auditing department to ensure that it never declines in their organizational fraud prevention.