The purpose of the study was to investigate the relationship between entrepreneurial motivation, innovation and resilience of tours and travel enterprises in Kampala. This study was a cross-sectional research design along with a quantitative research approach. A sample of 103 tours and travel enterprises was used. Data was obtained from business owners and top manager using questionnaire instrument. Validity of the questionnaire was tested using CVI, while reliability through pretesting and Cronbach Alpha coefficient. Data was analyzed using SPSS (v25) from which frequency tables, correlation and regression analyses were obtained to interpret results. This study found a positive relationship between entrepreneurial motivation and business resilience. The study also established a positive association between innovation and business resilience of tours and travel enterprises. Furthermore, the study found that entrepreneurial motivation and innovation significantly predict business resilience. Moreover, this study ascertained that entrepreneurial motivation is the better predictor of business resilience of tours and travel enterprises in Kampala. The study concludes that motivations or drives which propel entrepreneurial activity are crucial in ensuring business resilience. It further concludes that innovation plays a crucial role in ensuring business resilience. The study recommends tours and travel enterprises engagement in innovation; and entrepreneurship education to stimulate business resilience. This research suggests future researchers to examine relationship between entrepreneurial motivation and business resilience focusing on motivations other than locus of control, risk taking propensity, and achievement oriented; comparative study examining entrepreneurial motivation, innovation and business resilience; and quantitative and qualitative research.miu.ac.ug/publications 269 METROPOLITAN JOURNAL OF SOCIAL AND EDUCATIONAL RESEARCH ISSN: 1813-4270 Vol. 2 Issue 5, August - 2023, Pages: 269-279 approach examining entrepreneur motivation, innovation and business resilience among tours and travel enterprises in Uganda.