This study examined the relationship between project risk management, project resilience and project efficiency among health CBOs projects in Busoga Region. The study used a cross-sectional research design and a quantitative research approach. The sample size constituted 136 health CBOs from 214 located in the 10 districts of Busoga Region. Respondents comprised project manager, project monitoring and evaluation officer and a beneficiary. A structured questionnaire was used to obtain data. Data was analyzed using SPSS v.25 from where descriptive and inferential statistics were used to interpret findings. Mediation was tested using Med-Graph system. The study found a positive relationship between project risk management and project efficiency. The subcomponents of risk mitigation and risk assessment unlike risk monitoring and control were also found positively correlated with project efficiency. A positive relationship was ascertained between project resilience and project efficiency. Further, project adaptability, project competitiveness and project value subcomponents of project resilience were positively correlated with project efficiency. There was a positive relationship between project risk management and project resilience. Risk mitigation and risk monitoring and control unlike risk mitigation were positively correlated with project resilience. Both project risk management and project resilience were significant predictors of project efficiency. Moreover, the study found that project resilience is the better predictor of project efficiency. Further, it was ascertained that project resilience fully mediates the relationship between project risk management and project efficiency. The study concludes that as policy makers, managers and practitioners seek increase the rate of technical, financial and operational efficiency, they should bear in mind that project risk management and project resilience are critical factors which should be taken for granted. Moreover, drawing more attention towards project resilience will result in more project efficiency intensity. The study recommends; project adaptability, project competitiveness, risk assessment and risk mitigation.