The study examined the effect of workplace safety on health worker performance at Kilembe Hospital, Uganda. The study adopted a cross-sectional survey research design with mixed methods approach. A sample size of 152 respondents was considered for the study, 130 respondents participated, giving a response rate of 85.5%. The content validity index was calculated from, the questionnaire and it was 0.94 while the computed Cronbach’s alpha coefficient is 0.922 which is above 0.7 considered indicative of acceptable internal consistency therefore the questionnaire was deemed reliable. For qualitative data, to ensure consistency the KII and documentary review were guided by the research objective and question to keep the study focused. The study found that there was inadequacy of PPEs at Kilembe hospital which exposes health workers to risks of contracting diseases from patients and it was also found out that some of the hospital equipment were not functioning properly. This demotivates health workers and hence deters them from executing their mandate effectively. The study therefore, recommended that Ministry of Health should advocate for budget increment in order to enable them supply enough PPEs to hospital and the need for Government of Uganda through the Ministry of Health to partner with Civil Society Organization to fund some of the health budget for example repairing of hospital equipment.