The study was conducted from Uchumi supermarket Kampala Uganda under the topic “E-procurement and supply chain management”. The study had three major objectives to examine the e-procurement methods and procedures of Uchumi supermarket Kampala, to assess the management of supply chain of Uchumi supermarket and to establish the effect of e-procurement on supply chain management. The study was purely descriptive and analytical based on both qualitative and quantitative data from primary and secondary sources. From the findings, 70% strongly agreed and 30% agreed that electronic data interchange affected supply chain management, 52% said that sometimes online market places also affected supply chain management, 62% strongly agreed and 38% agreed that e-tendering greatly affected the management of supply chain and 545 indicated that sometimes online auction affects supply chain management. It was discovered that Uchumi supermarket uses the following e-procurement methods, electronic data interchange, e-tending, e-auctioning, e-market places and each method follow certain procedures. It was found out that supply chain management was far below the desired level. It was discovered that e-procurement affects supply chain management. It was also found out that e-procurement has affected supply chain management because of nonadherence to the set procedures of each method and even failure to implement some e-procurement methods like eauctioning and e-market places. The study therefore, concluded that e-procurement affects supply chain management. The study further made recommendations for improvements and for further studies.