The study aimed at entrepreneurship skills development on the social and economic transformation of women with a case study of Mengo, kampala and it was guided by the following objectives; To examine the influence of startup motive on female economic transformation in Mengo, Kampala, to establish the influence of creativity and innovativeness on female economic transformation in Mengo, Kampala and to examine the impact of risk taking on female economic transformation in Mengo, Kampala. The research design used in the research was descriptive research design. It involved collection and analysing of data in order to answer questions concerning the current status of the subject of study. The target population of the study was 239 respondents from Mengo. In the study, the reliability was established through the pilot-test whereby some items will either be adding or dropping to enable modification of the instrument. The data from the completed questionnaires was studied, re-coded and entered into the computer using the statistical package for social sciences (SPSS) version 21. Findings from the regression model indicated that 42.5% of the variations in the economic transformation were explained by creativity and innovativeness. The adjusted r square was less than the r square value because it put degrees of freedom into consideration. The model further identified from the coefficient (0.352) that a unit increase in the startup motive resulted into 0.352 units increase in the economic transformation. The researcher recommends the government to prioritize financial empowerment and resource allocation for village local councils to bolster their effectiveness. This entails a thorough review and adjustment of budgetary allocations across government levels, ensuring that village local councils receive adequate financial resources to execute their mandates successfully.