The study focused on the risks and effects climate change posed in Karamoja Sub region in North Eastern Uganda with attention on adaptation and mitigation strategies used in combating the effects and risks of climate change. Climate change policies, innovations aimed at decreasing the consequences and risks of climate change, climate risk assessment, and the effects of Uganda's climate change responses were all presented as study questions. A qualitative research design was used in the study, which included assessment of documentary sources as well as interviews. It was revealed that Uganda has implemented many policies related to climate change, according to a thorough analysis and presentation; however, a closer examination pointed that a number of policies were ineffective and did not directly address the issues of climate change. Several innovations for mitigating the consequences and hazards of climate change were also used though were insufficient. The report acknowledged that climate risk assessments were being conducted with little success and the responses had achieved some level of success in mitigating climate change's effects. Uganda government, as well as other non-governmental working groups on climate change, should step up the efforts in terms of tangible responses in the fight against global warming if the struggle against climate change is to be won.