The major objective of this study lied in finding out whether there was a relationship between Pesticides and Food Security in Kisoro Municipality, Kisoro District. Other objectives included: to establish the level of Pesticides application in Kisoro Municipality and to find out the extent of Food Security in Kisoro Municipality, Kisoro District. The study targeted 78 farmers, LC1 chairperson and Kisoro district agricultural officer. Data was analyzed by use of Microsoft excel and presented in form of frequency distribution tables and pie chart. SPSS Software was used to analyze data in the study. The researcher concluded that there is a very strong positive relationship between pesticides and food security at r = 0.745 and since the sig. value (.000) was far less than 0.01, which is the maximum level of significance required declaring a significant relationship between pesticides and food security, this implies that the when the level of pesticides application is high, the level of food security is also high because many crops grows to maturity without pest interferences and when the level of application of pesticides is low, the level of food security is also low. The researcher recommends the farmers to plant crops in large quantities so that they can feed the rapidly growing population in Kisoro District.