The study aimed at advertising and business growth in Kisoro district and it was guided by the following objectives; To find out the level of advertising in Kisoro Municipality, to find out the level of business growth in Kisoro Municipality and to find out the relationship between advertising and business growth in Kisoro Municipality. The research study obtained the study population for this study by dividing the sample population into the business men who involved in business for 5-years, local council III Chairperson and the commercial officer as the key informants of the researcher and the sample size was 28 respondents out of the total of 30 as the target population. Upon the findings of the study, the ANOVA table indicated that there is a significant relationship between advertising and business growth in Kisoro district. The regression model accounts for a significant proportion of the variation in business growth, with a sum of squares of 2.224 and a mean square of 4.224. The F-statistic of 61.295 and the p-value of .000 also suggest that the relationship between advertising and business growth is significant. Furthermore, the residual sum of squares is 8.746, indicating that there is still some unexplained variance in business growth that is not accounted for by the advertising variable. The total sum of squares is 10.970, indicating that the model explains a substantial proportion of the variance in business growth. Business men are required at all times to have a planned and systematic advertising campaign program in place, as this would help to make such promotional implementation effective. Business men should set up a more and effective sales promotion with the view to developing more promotional strategy in line with making profits. research.miu.ac.ug/publications 1657 METROPOLITAN JOURNAL OF BUSINESS & ECONOMICS (MJBE) ISSN 1813-4238 Vol. 2 Issue 3, June - 2023, Pages: 1657-1668