The major objective of this study lied in finding out whether there was a relationship between Industrial Discharge and Water Quality of Lake Victoria in Kalangala District. Other objectives included: To establish the level of Industrial Discharge into Lake Victoria, Kalangala District and to find out the extent of Water Quality of Lake Victoria, Kalangala District. With the help of Solvin's formula, the study used a descriptive and epidemiological method of inquiry and a simple random chance method of sampling to collect data from a sample of eighty participants near Lake Victoria in the Kalangala District. Given that there was a substantial positive correlation between industrial emissions and water quality (r = 0.994), and that the sig. value (.000) was much lower than the threshold level of significance of 0.01, which was necessary to declare a significant connection between industrial discharge and water quality, this suggested that industrial discharge had a significant impact on the water cleanliness of Lake Victoria. The study's conclusion on this goal was that there is very little water quality overall, which is caused by a high rate of industrial discharge into Lake Victoria's waters. The third goal is to determine the connection between industrial discharge and Lake Victoria's water quality in Kalangala District. The link between industrial discharge and water quality is highly positive. The study came to the conclusion that individuals in this region engage in numerous practices that cause water quality issues, such as disposing of human waste, sewage, and plastics straight into Lake research.miu.ac.ug/publications 1012 METROPOLITAN JOURNAL OF ENVIRONMENTAL AND HEALTH RESEARCH ISSN: 1813-4270 Vol. 2 Issue 3, June - 2023, Pages: 1012-1025 Victoria, which causes nutrient enrichment of water bodies and a decline in BOD. The researcher recommended the government to provide close supervision to industries in order not to dispose of industrial wastes directly into water bodies. K e y w o r d s : industrial discharge and water quality