The study aimed at establishing the influence of road network on the development of agricultural activities in Uganda with a case study of Buhehe district and it was guided by the following objectives; to examine the factors hindering agricultural activities in Busia district, to assess the nature of financial and government support which can be rendered to support farmers in Busia district and to analyze the challenges encountered by farmers when starting agribusinesses in Busia district. Although all the farmers wish to expand their market, only 66.7% of farmers supported the notion of forming partnerships with other people and entrepreneurs. Due to various reasons, a total of 33.3% farmers were against the establishment of partnerships. Their reasons vary from bad past experiences with partnerships or co-operatives, to witnessing challenges encountered by others and failure of other partnership initiatives. The study revealed that the small scale-farmers in this region were affected and limited by poor road infrastructure and that access to suitable water for irrigation was far from ideal. As a result, the sector did not perform to its full potential and this hinders economic development. Suitable and appropriate recommendations have been made to address the shortcomings identified in this research.